I read the Bruttel et al paper, watched the podcast with yourself and Alex, downloaded SnapGene, followed your instructions, had a play with it and read this Substack post which gave me a much improved understanding of the paper. Learning new stuff is always a pleasure but learning stuff of global importance makes that particularly poignant so thank you very much for taking the time to write this.
The Bruttel paper has received a lot of flack from those vested in maintaining the zoonotic spillover hypothesis particularly Anderson. Debate and the open discussion of alternative theories is a cornerstone of science, however Anderson's language and fervent desire to quash any dissent from the mainstream narrative appears bullish and somewhat desperate. Emotions aside I'd be genuinely interested to read your technical appraisal of Anderson's rebuttal to the Bruttel paper. You have a talent for translating the highly technical nuance's of genetics and cell biology into a more amenable technical framework that dumbo's like myself can comprehend.