The other big difference is in people’s reactions to dysphoria and how that can compound it.
When a cis woman loses her breasts to cancer and becomes dysphoric, if someone told her “well God made you have breast cancer, so getting a reconstruction would go against His plan for you and you’d deserve to go to hell” we would call that person a heartless monster. But when a trans woman feels dysphoric over the exact same body part and wants the exact same procedure, there are a billion people ready to tell her “well God made you a man, so transitioning would go against His plan for you and you’d deserve to go to hell” and somehow that’s a valid difference of opinion that must be respected on religious grounds. Well gee, I wonder which of those women is going to feel worse about her body.