Important avenue of inquiry, Derek, keep it coming. I am generally skeptical of taking any drug (especially for life) when a non-drug avenue exists, i.e. diet and exercise. That's great if GLP-1s reduce general inflammation, but what is the cause of that inflammation? Is it something that all humans are doomed to experience, or is it a product of the modern American diet and lifestyle? As with weight-loss surgeries, I would not feel good about resorting to such an intervention, knowing that if I changed my behavior without the surgery I would receive the same results. Also, there are benefits to diet and exercise beyond losing weight; I assume any doctor would recommend them over GLP-1s if their patients would stick to them.