Really interesting article, Derek! A secondary issue is how the GLP-1 variations on the market (like Zepbound, for example) pan out with respect to the proposed benefits. I think the proposed explanation that these artificial agonists work by reducing metabolic inflammation wherever they land is a good one - it is very well known that cellular inflammation is VERY bad for every part and parcel of the body that is subjected to it.

Having studied metabolism and neurophysiology in a former life, I can say with absolute certainty that the intricacies of the workings of many systems of the human body are mind-blowing - are true miracles - and we are just at the edges of beginning to understand how the systems work and interact with each other. As a student and then a researcher I can tell you without reservation that the more you learn about how your body operates, the more amazed you are at the processes, and the wilder it is to you that, for the most part, every single second of every single hour of every day all those myriad, intricate operations proceed successfully.