David, here's a discussion of a study published in Biochemical and Biophysical Research Communications. They used ivermectin to treat chronic myeloid leukemia and it helped -- it induced apoptosis in the leukemia cells and their stem/progenitor cells.

But the way it induced apoptosis was through oxidative stress and mitochondrial dysfunction.

https://www.cancertherapyadvisor.com/home/cancer-topics/chronic-myeloid-leukemia/ivermectin-induces-apoptosis-through-mitochondrial-dysfunction-in-cml-cells/

Same thing in this study of esophageal squamous cell carcinoma. Ivermectin induced apoptosis through mitochondrial dysfunction.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650430/

Same thing in this study of ivermectin for cervical cancer:

https://www.sciencedirect.com/science/article/abs/pii/S0041008X22002186

The authors thought that was great. Just use mitochondrial dysfunction to cure the cancer. But the problem is that mitochondrial dysfunction causes cancer. Here's a discussion of a study that showed the immune failure seen in cancer is caused by cancer cells depriving immune cells of energy by devouring their mitochondria.

http://haidut.me/?p=1696

My wife, who started life in science, cured her own glioblastoma and then, three years later, the glioblastoma of a friend's mother (who'd been sent home to die, given three months to live) with aspirin, of all things. Aspirin stimulates mitochondrial respiration. It can inhibit abnormal cell division, but promote normal cell division. In both cases, scans were free of tumors within a month and blood tests were back within normal range.

Essentially cancer seems to be devolution of cells to a more primitive state as a response to lack of energy. Help out your mitochondria and your cells have enough energy to return to full functioning and a non-cancerous state.

"Aspirin elevated ATP levels not only in intact cortical neurons but also in isolated brain mitochondria, an effect concomitant with an increase in NADH-dependent respiration by brain submitochondrial particles."

Neuropharmacology 2000 Apr 27;39(7):1309-18. Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices. Moro MA, De Alba J, Cardenas A, De Cristobal J, Leza JC, Lizasoain I, Diaz-Guerra MJ, Bosca L, Lorenzo P

So I'm wary of prolonged use of ivermectin because to me the rock bottom basis of good health is good mitochondrial function.

On the other hand, in this study they found ivermectin maintained mitochondrial ATP levels under SARS-CoV-2 hypoxia in cardiomyocytes, preventing heart failure.

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(17)30376-6/fulltext

https://pubmed.ncbi.nlm.nih.gov/28942281/

I certainly agree that maintaining mitochondrial ATP levels would work wonders for Covid patients. I just don't see how you get there when other studies are showing mitochondrial dysfunction from ivermectin.