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yes, this has been a complex and somewhat infuriating issue with covid data.

they do not break out outcomes by vaxx type and lump all inoculants together.

i have seen a lot of work showing that variant specific boosters fail to elicit novel response in those previously vaxxed, but those seem to be using the same modalities.

are you raising the possibility that because mRNA etc do not train to fight pathogen but rather cells infected by pathogen that perhaps training w/ a vaxx using live or attenuated virus might help remediate this issue?

that is striking me as somewhat implausible given that actually getting covid does not seem to do so so it would be surprising that a vaccine could.

how is the vaccine going to train in a manner that the pathogen itself cannot?

or am i misunderstanding your point?

Dec 26, 2022
at
9:06 PM

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