Nope. The science is well known... soluble fiber in your colon gets digested to SCFAs, which are then taken up by your colonic cells which release endogenous GLP-1 hormone into your bloodstream. Less soluble fiber, less GLP-1. So Ozempic, etc literally tickle the same receptors throughout the body that endogenous GLP-1 works on.

Your body literally gets a 'colon full of soluble fiber' signal from the drug. For many people that reduces appetite and helps with weigh loss, but these drugs presumably have myriad other biochemical effects other than weight loss, which mimic the effects of a high soluble fiber diet (and healthy microbiome). And in that way, it mimics a plant heavy (e.g. Mediterranean) or fully plant based diet.