Indeed. Keto is an excellent strategy that many people use effectively to lose weight. Ketosis also sends myriad signals throughout the body to change lots of metabolic factors. These signals are different from the GLP-1 signals (and downstream effects) that Derek is discussing in this post, that are independent of weight loss. Unfortunately, many who use a ketogenic diet for weight loss find that they regain their weight after a couple years.

Importantly, there is no large human population on earth that is living long-term in ketosis, to demonstrate long-term safety. Inuit peoples are the closest examples, and they developed a mutation long ago that causes them to NOT be in ketosis on a meat heavy diet! And they still suffer from rampant cardiovascular disease. This strongly suggests that long-term ketosis (and a mostly meat diet) is not healthy for humans. Short term RCTs suggest the same thing.

People attempting to live in long-term ketosis are doing a risky science experiment on themselves. Please be careful out there.