As a preface, it's been a while since I've gone over some of this in my head and jotted that comment down quickly, but maybe before reading my gibberish responses below, the following paper might present some of the ideas along the lines of what I'm saying...https://www.frontiersin.org/articles/10.3389/fimmu.2021.612747/full

(I don't know if it's 'good' and I probably have others, that was the 1st relevant one I found quickly)

Q: are you raising the possibility that because mRNA etc do not train to fight pathogen but rather cells infected by pathogen that perhaps training w/ a vaxx using live or attenuated virus might help remediate this issue?

A: I don't think that is necessarily the way I was trying to describe the action of the mRNA, but the more important aspect is really the latter...Yes, I am raising the possibility that, based on some of those other observational studies (Time to change the paradigm? paper) there could perhaps be remediative effects from certain other types of vaccines (see more below). And per the IgG4 quote above, perhaps 'heterologous prime/boost' vaccine strategies could be something to look at more closely (and purposefully, not just cause you couldn't get another vaccine!).

Q: that is striking me as somewhat implausible given that actually getting covid does not seem to do so so it would be surprising that a vaccine could.

A: But "Who" are we talking about "getting covid"? Previously mrna 'trained/fixated' people or unvaxxed? I think as you stated, based on the article, "what we are seeing here is the near total elimination of IgG3 response in the boosted, especially in those (gray circles) who got breakthrough infections". So we're seeing evidence for what we've thought for quite a while - that vaxxed getting covid (being exposed to the pathogen) may actually be continually degrading their future responses (because mrna 'trained' them to respond so poorly) - and scarily to other pathogens maybe as well.

Q: how is the vaccine going to train in a manner that the pathogen itself cannot?

A: My supposition/hope is different vaccines (i.e. heterologous prime/boost) would elicit altered responses in mRNA trained/fixated people. The very fact that adenovirus 'vaccines' do not seem to elicit the detrimental IgG4 response (homolgous or heterologous) would seem to give some credence to this (as does the above referenced NSE effects paper comparing adenovirus to mrna covid 'vaccines' - in previous comment).

Is this because the actual adenovirus vector invokes its own (additional) innate/adaptive responses vs. the mRNA fixated response? Could an inactivated whole virion vaccine (with innate immune system-activating TRL 7/8 agonist) which induces Th1 (cell mediated) response to the whole virus (not just spike) reprogram both innate and adaptive responses of mrna trained people? And similarly, to your point, might an inactivated whole virion (w/'typical' alum adjuvant) and a live attenuated vaccine (w/o adjuvant) just invoke a similar response as a covid infection and therefore not 'work' in this manner?

I think 'order of operation' so to speak may be critical if we are to see these effects. Whether any (other) vaccination has ability to (re)train the immune system is me being more hopeful (based on some of the refs listed) than knowing. I'm not sure anyone really 'knows' let alone should have had hubris to act in the ways they have, but I do feel like there is some remediative potential with such strategies.

Q: or am i misunderstanding your point?

A: No, I don't think so. It's probably just cause I am not a Julliard trained immunologist/virologist and so could not explain it clearly! :P