Improving antitumor T cells

Science. 2022 Nov 11;378(6620):598. doi: 10.1126/science.adf0546. Epub 2022 Nov 10.

Abstract

Disrupting cell cycle regulators can overcome anticancer T cell dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Cycle* / genetics
  • Cell Cycle* / immunology
  • Humans
  • Immunotherapy, Adoptive*
  • Mediator Complex*
  • Neoplasms* / immunology
  • Neoplasms* / therapy
  • T-Lymphocytes* / immunology

Substances

  • MED12 protein, human
  • Mediator Complex