Two new chamigrane metabolites from fermentation broth of Steccherinum ochraceum

Dong-Ze Liu; Ming-He Luo

doi:10.1016/j.fitote.2010.08.004

Two new chamigrane metabolites from fermentation broth of Steccherinum ochraceum

Fitoterapia. 2010 Dec;81(8):1205-7. doi: 10.1016/j.fitote.2010.08.004. Epub 2010 Aug 17.

Authors

Dong-Ze Liu¹, Ming-He Luo

Affiliation

¹ Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. dongzeliu@scsio.ac.cn

PMID: 20723585
DOI: 10.1016/j.fitote.2010.08.004

Abstract

Two new chamigrane-type metabolites named steperoxides C (1) and D (2) were isolated from the basidiomycetes Steccherinum ochraceum. The structures of 1 and 2 were established on the basis of spectral methods (MS, IR, ID and 2D NMR experiments). Compounds 2 showed significant antimicrobial activity against Staphylococcus aureus at 10 and 5 μg/disk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / metabolism
Anti-Bacterial Agents / pharmacology
Basidiomycota / chemistry*
Basidiomycota / metabolism*
Dose-Response Relationship, Drug
Fermentation
Heterocyclic Compounds, 3-Ring / chemistry*
Heterocyclic Compounds, 3-Ring / metabolism
Molecular Structure
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Heterocyclic Compounds, 3-Ring
steperoxide C
steperoxide D