A clinician just messaged me that an apoB concentration of 90 mg/dL is normal. Below are the apoB reference ranges from Framingham Offspring Study: 90 mg/dL is the 40th population percentile cut-point - I replied: I sure hope you are not comfortable letting patients have such a level. If you are see the link below - The people who do not get ASCVD have hypobetalipoproteinemia - basically an apoB < 50 mg/dL or lower (they also have little downside to their physiologic apoB.. Link is https://lnkd.in/gtHZx43t National Lipid Association European Atherosclerosis Society
Great article! I wish more clinicians were more aggressive (and agressive early) at making the lipid profile as "normal" (i.e. low risk) as possible. We now have the tools to do so (for the most part....although we're working on Lp(a)).
Judith Collins
6mo
I need to convince our hospital lab that ApoB of 90 is not normal/desirable. Aside from EAS, are there US lab norms I can refer them to that promote the above goals?
Debbie Laurune
5mo
LDL of 57, but apoB is72. I thought LDL tracked with apoB?
Judith Collins
6mo
Part of the problem are labs indicating 90 is desirable/normal level.
Owner/ Medical Director at Advocate MD
6moThomas Dayspring, MD FACP, FNLA what are you thoughts- patient with elevated apoB but negative Coronary Calcium score? Some argue that this doesn't need to be treated. I am thinking apoB elevation will show up before and is precursor to calcium deposition in the vessels so you still want to treat?