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Germ “theory” defenders say Koch’s 2nd postulate—pure culture—is optional. But Koch knew the presumed cause must be isolated to act as a true independent variable. It's the foundation of "infectious" disease research. Without that, you can’t test causation. That’s basic science.
Modern microbiologists and virologists relaxed this rule when they couldn’t isolate certain bacteria or “viruses.” No isolated IV = no reliable test. No test = no science. That’s why Koch’s 2nd postulate matters—it’s not optional. No pure culture = no scientific foundation.
For more on the importance of the pure culture and the necessity of a valid independent variable:
Purification/Isolation
The Scientific Method
Koch's Postulates
Nov 13
at
1:38 PM