Methylation and creatine

Let’s break this down a little further and discuss how methylation fits in. Creatine levels are sustained mostly by endogenous production, which requires the functioning of the enzymes I mentioned above, plus the amino acids glycine, and arginine. One of these enzymes, glycine amidinotransferase (GAMT) requires methylation by SAMe, which is the end product of the methylation cycle. Without GAMT receiving a methyl group from SAMe, creatine can NOT be synthesized. I’m going to be writing a lot about methylation in this newsletter, and have chosen to talk about creatine by way of introduction to this critical process, as creatine synthesis accounts for 45-70% of a person’s entire output of SAMe, which is the principle methyl donor in the body for a great many critical purposes. (1)