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Double-stranded RNA (dsRNA) can trigger several negative pathologies in humans, including autoimmune diseases, inflammation, and antiviral resistance. Here are some of the possible consequences:

Autoimmune diseases: dsRNA can trigger the activation of the innate immune system, leading to the production of pro-inflammatory cytokines and chemokines. This can result in the activation of autoreactive T cells, causing autoimmune diseases like lupus, rheumatoid arthritis, and multiple sclerosis.

Inflammation: dsRNA activates the production of type I interferons (IFNs), which play a crucial role in the antiviral response. However, excessive or uncontrolled production of IFNs can lead to chronic inflammation and tissue damage, contributing to various inflammatory diseases, such as atherosclerosis, asthma, and cancer.

Antiviral resistance: dsRNA can also trigger the expression of antiviral proteins, such as protein kinase R (PKR) and RNase L, which inhibit viral replication. However, this response can sometimes lead to the development of antiviral resistance, allowing viruses to evade the host's immune system and persist in the body.

Oncogenesis: dsRNA has been implicated in the development of cancer. For example, the dsRNA-triggered activation of the JAK-STAT pathway can lead to the expression of pro-tumorigenic genes and promote tumor growth.

Neurological disorders: dsRNA has been linked to various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. This may be due to the activation of the innate immune system in the central nervous system, leading to inflammation and neuronal damage.

Vascular diseases: dsRNA has been shown to promote endothelial dysfunction and contribute to the development of vascular diseases, such as atherosclerosis and hypertension. This may be due to the dsRNA-induced activation of pro-inflammatory and pro-thrombotic pathways.

In summary, dsRNA can have detrimental effects on human health by triggering autoimmune diseases, inflammation, antiviral resistance, oncogenesis, neurological disorders, and vascular diseases.