It would be good to mount the seemingly insurmountable problems associated with making next-gen covid vaccines.

Looking beyond one or two covid infections - and looking at say 10 or 20 covid infections over the next 20 years, the question arises about what endemicity looks like? I just read 'SARS-CoV-2 and "Textbook" Immunity' on the JohnSnowProject website. One of the long-term endemicity models looked like this and I'd be interested to hear your view?

"At some point the [organ and immune system] damage accumulated, together with the accelerated immune system aging we discussed earlier plus normal aging processes, can reasonably be expected to outweigh the protective benefits of the memory B and T cells developed from previous infections. As a result, the baseline risk shifts higher - eventually much higher than what it would be at a given age for a first infection."

If true, it's worth trying to surmount the insurmountable.