Thanks for putting this together! I tend to approach the missing heritability debate from only the empirical side since I don’t have a super strong background in population genetics theory, so this writeup was helpful. I think my one question was about the Simons et al results. If I understood the paper correctly, they assume a process governed by stabilizing selection. However, with the recent Reich lab paper raising the possibility of directional selection on IQ, I was curious how the results would change under directional selection. My guess is that the selection coefficients would be greater, and thereby imply greater rare variant heritability?
May 21
at
1:20 AM
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