Yes, both good and bad. Good: I have been lucky enough to have many symptomatic improvements (things like swallowing problems, bladder problems, intention tremor, foot drop and other symptoms have either improved or disappeared altogether) - bonus! Bad: I now have avascular necrosis which was caused by the steroids used during HSCT, and also secondary immune deficiencies, probably caused by the Rituximab used during HSCT. I would still choose to have HSCT, though.

At last! As a person with MS (PPMS) and a long-term proponent of HSCT who has long been frustrated by the stand taken by many neurologists, I applaud your current reasoning. My neurologist in Oxford told me seven years ago that I would be brought back in a box in I had HSCT. My haematologist in Oxford told me seven years ago that he couldn't understand why neurologists weren't referring their MS patients to him for HSCT. He supported my decision to have HSCT, especially as at that time ther…

Boffa et al. for the Italian BMT-MS study group. Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis. Neurology. 2021 Jan 20:10.1212/WNL.0000000000011461. doi: 10.1212/WNL.0000000000011461.

Objective: To determine whether autologous hematopoietic stem cell transplantation (aHSCT) is able to induce durable disease remission in people with multiple sclerosis (MS), we analyzed the long-term outcomes after transplant in a large cohort of MS patients.

Methods:…