What is Valproate Sodium? Valproate Sodium is used to treat various types of seizure disorders. This medicine is sometimes used together with other seizure medications. Valproate Sodium is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches. Valproate Sodium may also be used for purposes not listed in this medication guide. Valproate Sodium side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if the person taking Valproate Sodium has signs of liver or pancreas problems, su…