Table 1 Diagnoses within 90 days of exposure for study sample with documented COVID-19 vaccination (n = 284,592)

From: Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection

Diagnosis

No. new diagnoses

New diagnosis before exposure

New diagnosis after exposure

Post-exposure risk

Diagnostic group

n (per 100,000)

n (per 100,000)

n (per 100,000)

Odds (95% CI)

P value

Myocarditis

25 (8.78)

7 (2.46)

18 (6.32)

2.57 (1.02–6.77)*

0.046

Myocarditis

Dysautonomia

68 (23.89)

21 (7.38)

47 (16.51)

2.24 (1.30–3.87)†

0.002

POTS

POTS

1,264 (444.14)

501 (176.04)

763 (268.10)

1.52 (1.36–1.71)‡

<0.001

POTS

Mast cell disorders

64 (22.49)

27 (9.49)

37 (13.00)

1.37 (0.81–2.32)

0.26

POTS

UTI

2,038 (716.11)

879 (308.86)

1,159 (407.25)

1.32 (1.21–1.44)‡

<0.001

CPC

Dizziness

2,191 (769.87)

954 (335.22)

1,237 (434.66)

1.30 (1.19–1.41)‡

<0.001

CPC

Lumbago

2,845 (999.68)

1,256 (441.33)

1,589 (558.34)

1.27 (1.17–1.36)‡

<0.001

CPC

Fatigue

3,090 (1,085.76)

1,377 (483.85)

1,713 (601.91)

1.24 (1.16–1.34)‡

<0.001

POTS

Edema

1,196 (420.25)

533 (187.29)

663 (232.97)

1.24 (1.11–1.40)‡

<0.001

CPC

Hyperlipidemia

4,373 (1,536.59)

1,952 (685.89)

2,421 (850.69)

1.24 (1.17–1.32)‡

<0.001

CPC

Hypertension

4,639 (1,630.05)

2,080 (730.87)

2,559 (899.18)

1.23 (1.16–1.30)‡

<0.001

CPC

Iron deficiency anemia

1,688 (593.13)

757 (265.99)

931 (327.13)

1.23 (1.12–1.36)‡

<0.001

CPC

Anxiety

2,929 (1,029.19)

1316 (462.42)

1,613 (566.78)

1.23 (1.14–1.32)‡

<0.001

CPC

Depression

1,737 (610.35)

795 (279.35)

942 (331.00)

1.18 (1.08–1.30)‡

<0.001

CPC

GERD

2,795 (982.11)

1,308 (459.61)

1,487 (522.50)

1.14 (1.05–1.23)‡

<0.001

CPC

Cellulitis

1,799 (632.13)

844 (296.56)

955 (335.57)

1.13 (1.03–1.24)*

0.01

CPC

Eczema

1,799 (632.13)

844 (296.56)

955 (335.57)

1.13 (1.03–1.24)*

0.01

CPC

Diabetes mellitus

1,269 (445.90)

600 (210.83)

669 (235.07)

1.12 (1.00–1.25)

0.06

CPC

EDS

40 (14.06)

19 (6.68)

21 (7.38)

1.11 (0.57–2.14)

0.87

POTS

Headache

2,292 (805.36)

1,096 (385.11)

1,196 (420.25)

1.09 (1.00–1.19)*

0.039

CPC

  1. CI, confidence interval; GERD, gastroesophageal reflux disease.
  2. Odds of post-exposure diagnosis were estimated using one-sample proportions testing with continuity correction, and two-sided P values are shown without correction for multiple testing while noting that a conservative Bonferroni threshold of 0.05/20 = 0.0025 may be considered for aiding interpretation of results.
  3. *P < 0.05, †P < 0.01, ‡P < 0.001.
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