Alex Kesin (@alexkesin): "You'd be surprised how much of the fundamental target discovery literature relies on tool compounds with terrible molecular properties… poor specificity, awful bioavailability, so on. It makes you wonder whether some of these studies are even hitting the intended target at all"

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You'd be surprised how much of the fundamental target discovery literature relies on tool compounds with terrible molecular properties… poor specificity, awful bioavailability, so on.

It makes you wonder whether some of these studies are even hitting the intended target at all

If you are operating in an academic environment, the most important shift you can make is to begin designing your program with the end drug in mind. Incorporating a Target Product Profile early, generating evidence of drug-like properties, and thinking through the development path will materially increase the likelihood of translation.

Juan Cueva

Apr 4

9:30 PM

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