Thank you for your input. I know you cannot diagnose over Substack (though maybe these days that might be better!!!) but I'm only taking one tab (maybe two) per week of metformin. I picked this idea up from Doctor from Cornell med school talking at a conference (I automate hospitals for a living, PACS, EHRs, etc) . My own endocrinologist (I am in Naperville/Aurora IL area, DuPage Medical Gp, now Duly... and totally into the Big Medical stuff now....) said there is still not a lot known about IGF-1, except of course it is a growth agent - good for kids, not for someone in his 60s. Mine was up around 290 or so. I had a bit of a bout of cancer 5 years ago (fine now), but don't want any more "surprises." It's now half that doing 1/wk metformin, 3x/week berberine, walnuts (below) and time restricted eating, among other things. But again, I know you can't diagnose over substack!!!!

Another article said about walnuts and IGF-1 "they could have an extraordinary secret weapon against cancer: a trio of potent antioxidants that include tellimagrandin, juglone, and morin. Not only do these compounds reduce oxidative stress and inflammation that can trigger cancer, but studies have shown that they can suppress levels of a hormone known as IGF-1, which researchers say plays a key role in breast cancer. Research seems to support the cancer-fighting powers of walnuts. In one animal study, scientists found that the equivalent of two handfuls a day of walnuts cut risk of breast cancer by 50 percent.7 And, a study published in the International Journal of Oncology reported that morin has strong anticancer activity against human colon cancer cells.