Not many realize how profoundly unsettling QM was to not just physics but to the philosophical foundations of scientific method.

I read one paragraph in a book by Karl Popper comparing intractability with the ultimate unknowability dictated by Heisenberg’s Uncertainty Principle; it was some of the clearest thinking in my experience.

It was not all that long ago that to claim to, or even to seek to, understand how things actually worked (“realism”) was regarded as conceit and unscientific.