The brain makes its own cholesterol, but statins can disrupt that. Two kinds of statins, hydrophilic, like crestor, and more conventional lipophilic like atorvastatin. There's a natural barrier called the blood brain barrier that prevents many toxins from seeping into the brain, which the body goes to great lengths to protect. Some statins in lipophilic class can penetrate the blood brain barrier, reducing cholesterol production where we need it most -- in the brain. Our cholesterol fetish has driven statin use to almost universal. At the same time, we've has an increase in dementia conditions. Not "proven" causation, but close enough for me. Good Calories Bad Calories (Taubes) and Carnivore Code (Saladino) make a good case that arterial plaques aren't caused by cholesterol, but by insulin. And no studies have ever shown that statins increase lifespan. But they significantly increase profits for pharma and prescribers. It's another scam by the medical industrial complex.