Interesting article, though I must respectfully point out a frequent misunderstanding about membrane-associated versus aqueous localization: membrane potentials differ from ionic charges. Redox potentials cannot be assessed solely with the Nernst equation; the Goldman equation should also be applied, since oxidants do not act like typical drugs. Excessively high redox potential leads to oxidative stress, so higher levels are not necessarily better. CDS easily crosses lipid barriers because of its molecular size, which explains its effectiveness against biofilms.