Thank you for this wonderful article. This is a sad chapter in medicine. Unfortunately, the tragedy is based on a fundamental misconception about biology, i.e., that it is ultimately malleable. As a biological psychologist, I can assure you that it is not. No intervention is without its risks and unintended consequences, some of which can be profoundly detrimental. Thank you again for your very thoughtful and thought-provoking article. Sincerely, Frederick