A drug that affects the reward system—the exact system that malfunctions in depression, anxiety, addiction, eating disorders, and basically every condition that makes people want to not be alive—was tested almost exclusively on people without any of those conditions. The trials that got these drugs approved for obesity specifically excluded people with major depression. The very population most likely to experience psychiatric effects—and most likely to be harmed by them—was deliberately kept out of the research that determined whether the drug was safe.