Dr. Rennebohm highlighted the right point – why Dr.Bossche expects increased SC-2 virulence – because SC-2 shall migrate from URT to LRT on migratory DCs. Increased virulence is not caused because of immune evasion of both humoral and CTL directed immunity as Dr. McMillan alluded to.

Migration from URT to LRT implies that vaccinal humoral response exerts increased non-neutralizing pressure on S-NTD in the URT.

Both arguments: on virulence and vaccine induced immune response in URT, are flawed, because tissue resident DCs ≠ migratory DCs in the URT, and parenteral vaccination do not induce considerable immune response in the URT, where multimeric SIgAs and tissue resident immune cells prevail in similar fashion both in vaccinated and unvaccinated. Dr.Bossche mashed migratory DCs with tissue resident DCs as they are the same. And Dr.Bossche mashed mucosal immunity in the URT with systemic immunity as if they did not have separates departments of prevalence.

The main benefit one can get from Dr.Bossche’s analysis is increased energy caused by adrenal hormone release after reading his analysis.