The rate limiting step in treating Lyme is the biofilm the organism slathers itself with. You can be on all the right antibiotics for years but if the biofilm is not dealt with there will be a relapse. The infection also leaves persister cells and one has to be on a maintenance protocol to keep those torpid cells inactive.

While not everyone can tolerate Alinia, this drug is the most effective biofilm destroyer I have ever come across.... I detail this in my book Incurable Us published last month.

Alinia is also called Nitazoxinide.

Also, if a Lyme patient has been on Doxycycline previously, and then stopped taking it.... it can't be reused. The Lyme organism becomes very resistant to doxycycline and it can only be used once because of that. I mention this because many with Lyme do get treated with doxy, and inadequate course of doxy but nevertheless taking again or a second round or third round is a waste of time if the drug was paused or there was a hiatus from using it.