Clozapine has been a highly underutilized drug for decades psychiatryonline.org/do…

40+ years ago when people were investigating the mechanism of action of clozapine, they knew that some of its benefits might have had to do with muscarinic receptors as well. In fact, some of these investigations were done at Pfizer!

The story of how they turned xanomeline to cobenfy by creating a combination therapy to optimize therapeutic benefit over side-effects though is fascinating. Thanks to Trevor Klee for telling this story.