Democrats have been prisoners of the consultant class and the interest groups for too many years: playing little games of triangulation and demographic tag and RightThink/WrongThink that appeal to narrower and narrower subsets of the population. And there are elements of "wokeness" that are truly alienating and annoying, as anyone can testify who has ever said "homeless" and been lectured loftily and snottily for their failure to say "unhoused."
The worst aspect of Democratic popular politics is an elitist loathing for Those People, working people, "the kind of people who vote for Republicans." Democratic politicians try to avoid saying anything too blatantly contemptuous of the white working class, although they come out with an occasional riff on God, guns, and gays, or baskets of deplorables, that backfires badly on them.
But left-leaning social media, the world of Wonkette and Raw Story and Kos, are chock-a-block with ordinary people (boosted by the occasional mischief-making troll) who feel it's legitimate to heap loathing and contempt on all Republicans---to declare that anyone who would vote for a Republican is clearly motivated by raw evil: they are all racists, they are all fascists, they are all wicked and bad, they deserve to suffer, they voted for [fill in the blank with the outrage of the day], bad cess to all of them.
Outside of a small Maga core, this contempt and loathing for Republican voters is not only misplaced, but profoundly destructive: it slams doors that should be left open, it makes communication impossible, and it adds to the sense that Democrats are not merely elitist but also snottily cruel.
The Trump voters I know are perfectly kindly people. By my lights they're misguided (by their lights, I'm the one who's misguided) but we can communicate with affection and respect: they are as patient with me as I am with them, and we learn from each other. Landrieu is basically recommending living by the Golden Rule. It's not bad advice.