America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.
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The whole concept of vaccination depends on herd immunity as no vaccine is 100% effective. Based on that, one off exceptions should have little-to-no impact on the herd’s immunity.
That said, once you reach a certain threshold (depending on class/school size, etc.) returns diminish significantly. So if “one offs” become “most students” then there’s a deeper problem to address.