Top page of search results, "Methylene Blue Toxicity"

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ncbi.nlm.nih.gov › books › NBK557593

Methylene blue is a medication used in the management and treatment of methemoglobinemia, a condition in which hemoglobin decreases its ability to carry oxygen. This activity reviews the indications, action, adverse effects, and contraindications for methylene blue as a valuable agent in the therapy of methemoglobinemia, vasoplegic syndrome, Plasmodium falciparum, and ifosfamide-induced ...

journals.lww.com/joacp/Fulltext/2010/26…

Methylene blue is a safe drug when used in therapeutic doses (<2mg/kg).But it can cause toxicity in high doses. The features of toxicity being cardiac arrhythmias, coronary vasoconstriction, decreased cardiac output, renal blood flow and mesenteric blood flow; increased pulmonary vascular pressure & pulmonary vascular resistance and gas ...

accessmedicine.mhmedical.com › content.aspx?sectionid=248385909

METHYLENE BLUE | Poisoning & Drug Overdose, 7e | AccessMedicine ...

Indications. Methylene blue is used to treat methemoglobinemia if the patient has symptoms or signs of hypoxemia (eg, dyspnea, confusion, or chest pain) or a methemoglobin level higher than 30%. Note: Methylene blue is not effective for sulfhemoglobinemia. Methylene blue has been used to reverse and prevent ifosfamide-related encephalopathy.

pubmed.ncbi.nlm.nih.gov › 20142303

CNS toxicity involving methylene blue: the exemplar for understanding ...

Methylene blue has only recently been noted to cause severe central nervous system toxicity. Methylene blue is used for various conditions, including, intravenously, in methemoglobinemia, vasoplegia and as an aid to parathyroidectomy (at doses of 1-7.5 mg kg(-1)). This review of the current evidence concludes that 13 of 14 of the reported cases ...

sciencedirect.com › science › article › pii › S2590123022003486

Methylene blue dye: Toxicity and potential elimination technology from ...

Toxicity effects of methylene blue dye. 3. Removal strategies for methylene blue. Methylene blue has strong affinity for water at normal temperature condition [61] and also generally known to be difficult to biodegrade and remove from wastewater using simple conventional treatment methods [62, 63].

en.wikipedia.org › wiki › Methylene_blue

Methylene blue is a monoamine oxidase inhibitor (MAOI), and if infused intravenously at doses exceeding 5 mg/kg, may precipitate serious serotonin toxicity, serotonin syndrome, if combined with any selective serotonin reuptake inhibitors (SSRIs) or other serotonin reuptake inhibitor (e.g., duloxetine, sibutramine, venlafaxine, clomipramine ...

mdpi.com › 2073-4441 › 14 › 2 › 242

The unavailability of clean drinking water is one of the significant health issues in modern times. Industrial dyes are one of the dominant chemicals that make water unfit for drinking. Among these dyes, methylene blue (MB) is toxic, carcinogenic, and non-biodegradable and can cause a severe threat to human health and environmental safety. It is usually released in natural water sources, which ...

fda.gov › drugs › drug-safety-and-availability › fda-drug-safety-communication-serious-cns-reactions-possible-when-methylene-blue-given-patients

CNS reactions possible when methylene blue is given to patients t...

It is believed that when methylene blue is given to patients taking serotonergic psychiatric medications, high levels of serotonin can build up in the brain, causing toxicity. This is referred to ...

pubmed.ncbi.nlm.nih.gov › 18685714

Toxicology and carcinogenesis studies of methylene blue ... - PubMed

Methylene blue trihydrate has a variety of biomedical and biologically therapeutic applications. Methylene blue trihydrate was nominated by the National Cancer Institute (NCI) for carcinogenicity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of methylene blue trihydrate, as well as the inadequate animal data on ...

ncbi.nlm.nih.gov › pmc › articles › PMC6086742

Revisiting the physiological effects of methylene blue as a treatment ...

Results. Methylene blue was found to be innocuous up to 50 mg/kg. KCN infusion (0.75 mg/kg/min) killed all animals within 7-8 min. MB (20 mg/kg) administered at the same time restored blood pressure, cardiac contractility and limited O 2 deficit, allowing all the animals to survive, without any significant methemoglobinemia. When administered 5 min after a non-lethal CN intoxication, MB sped ...

apsf.org › article › methylene-blue-and-the-risk-of-serotonin-toxicity

Methylene Blue and the Risk of Serotonin Toxicity

Methylene blue, unlike indigo carmine, is a potent MAO inhibitor and when combined with a variety of medications with serotonergic activity, may contribute to serious sequelae secondary to serotonin toxicity. Specific commonly encountered serotonergic medications include SSRIs like fluoxetine, paroxetine, and escitalopram, serotonin ...