My first reaction when I see studies like this is always a question about the population. What qualifies as clinical depression in these scales? If you dig into that question, you find that depression can mean a staggering range of things. A grief response. A developmental arrest. A somatic pattern wired in from early childhood. A spiritual emergency wearing a clinical mask. Collapsing all of that into a single Hamilton score and then asking whether six weeks of psilocybin moved the number is a very strange way to study human suffering.