This is a great post on daraxonrasib, the recent breakthrough drug for pancreatic cancer, by Ruxandra Teslo

She explains that pancreatic tumors are hard to treat for several reasons:

- they're usually caught late (after they've spread to other organs)

- they physically wall themselves off from the immune system with dense scar-like tissue and also suppress immune activity from within

- the most common driver mutation, KRAS, sits on a protein with no obvious binding site for conventional drugs...

... until now!