Thank you once again AMD for a great article on the safety of DMSO. I ordered DMSO immediately after your first article appeared. I am now in the 4th week of testing DMSO for Parkinson's diseasr. I followed the recommended dosing schedule starting at 3.5g/day taken orally and scaling up to 14g. It soon became clear to me that this was too much as I had severe headache and brain fog, so I decided to take a break. On the second day of the break my Parkinson's symptoms almost disappeared and I felt better than I had felt for ages. The biggest improvement was in relief from bradykinesia. After being slow for the past years, I suddenly became Mr Speedy.

I was diagnosed with PD in 2018 and I'm not new to alternative therapies for PD that bring real benefit to patients so this came as no real surprise to me. I have been treating my PD with sulforaphane in a Broccoli Seed Tea (BST) that I created in 2020. Sulforaphane is a potent activator of the Nrf2 pathway that controls oxidative stress and improves mitochondrial function. BST is very effective in attenuating non-motor symptoms of PD, particularly constipation, brain fog, fatigue and urinary urgency, but it has little effect on motor symptoms. DMSO seems to be complementary to sulforaphane in that it attenuated motor symptoms. I suspect that sulforaphane does not easily cross the BBB whereas DMSO does. I am now dosing at 2g/day applied topically and doing well. At this dose I get minor brain fog for about one hour and the benefits of DMSO for the rest of the day. Once I am satisfied that I have a good idea of the dose range, benefits and any side effects, I will discuss how to go forward with the group of PD patients who currently use BST (about 50 worldwide). My intention is to try to define a protocol for a small number of n=1 tests by people in the BST group on the basis of self-experimentation in order to get a more representative idea of what DMSO can do for PD. I'll keep you posted of the progress.