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I think that the kind of control experiments required for virology to be validated and the alternative hypotheses to be tested have already been clearly stated by more than one person. For example, Stefan Lanka has proposed that there are 7 steps used in virology and that each of these steps needs to be validated using appropriate controls.
Just to take the first of these steps, the cell culture, the alternative hypothesis is that it is the starvation of the cells and addition of antibiotics that causes the effects, rather than the ASSUMED presence of a virus. The type of control experiment prescribed is to perform the same steps but without the addition of a human sample alleged to contain a virus, and this type of control experiment has already been conducted multiple times and is currently being conducted again more rigorously by a team of scientists. These experiments show that the alternative hypothesis is correct and the assumption of the presence of viruses is solely that—an assumption..
These experiments of themselves challenge the core of modern virology since the cell culture is a gold standard for alleged “virus isolation” since 1954.
Other kinds of control experiments would address other methodologies to see if these questionable methodologies and protocols—genome sequencing for example— have any validity. There are already plans for these experiments to be conducted.