I really appreciate this post, both in terms of your analysis and synthesis and the sources and links. Following up on your last paragraph, any thoughts on what to do with the term "anti-depressants"? Is there a term that does justice to the possible treatment mechanisms or symptoms/traits treated? (a term for communicating with patients and the lay public). Or given the complexity, is it better to avoid such a term? Also, is there a one-sentence explanation of how serotonergic drugs work that you provide to your patients? Or do you describe several possible accounts?