True. Here are some of the findings from the Netherlands long-term followup of trans adults who started blockers (GnRHa) and/or hormones (GAHT) in adolescence (ages 12+):

Decision-making, long-term use, satisfaction

• The benefits of blockers outweigh any risks, but withholding treatment causes too much harm to justify withholding (Kreukels 2011)

• Adolescents are capable of making medical decisions through informed consent for beginning puberty blockers (Vrouenraets 2021)

• Earlier is better: Youth referred to the gender identity clinic younger than 14 had better mental health than those who presented after 14, likely due to the older teens’ stress from puberty (de Rooy 2024)

• 98% of transgender adolescents who started puberty-delaying medications then hormones continued to use hormones 4 years later (van der Loos 2022)

• Trans youth who had blockers then hormones had “clear ideas about their gender identity and treatment wishes.” Trans youth who had blockers but decided against hormones saw using blockers as an extended exploratory stage. That is, blockers served their purpose well (Vrouenraets 2022)

• The number of people seeking transgender-related care increased from 1972 to 2015, but the regret rate for gonadectomy remained extremely low (<1%) (Wiepjes 2018)

• The increase in youth seeking care is due to increased acceptance of seeking care, and not that people with lower intensities of dysphoria or worse psychological functioning are seeking care (Arnoldussen 2022).

Mental Health & Executive Functioning

• Transgender adolescents had worse psychological well-being before treatment, but after starting puberty blockers, they experienced similar or better psychological functioning compared to their cisgender peers (van de Miesen 2020).

• Blockers decreased behavioral and emotional problems and depressive symptoms in transgender adolescents, with no withdrawal, loss-to-follow, or discontinuation (de Vries 2011, J Sex Med)

• Blockers, hormones, and surgery (at 18+) relieved gender dysphoria for transgender adolescents still years later, and they had psychological functioning on par with the general population (de Vries 2014)

• Transgender youth on hormones had IQs and educational achievement on par with their cisgender peers (Arnoldussen 2022, Clin Child Psych)

• Executive brain function was similar in trans adolescents on blockers compared to those not on blockers and also compared to cisgender adolescents (Staphorsius 2015)

• Trans folks had improved satisfaction with physical appearance and feelings of self-worth 6 years after hormones (as older teens) and 1.5 years after gender-affirming surgery (at 18+) (Arnoldussen 2022, LGBT Health)

• The majority of adolescents with gender dysphoria diagnoses did not have co-occurring psychiatric conditions (de Vries 2011)

Physical Health & Appearance

• No evidence of long-term effects of puberty suppression on sexual satisfaction and dysfunction (van der Meulen 2025)

• Blockers then hormones do not compromise cardiovascular health (Klaver 2020)

• After 15 years of blockers then hormones, bone mineral density in transgender young people decreased slightly on the blockers, but returned to baseline levels on hormones (van der Loos 2023; Shagen 2020)

• Transgender girls on puberty blockers then hormones were on average only slightly shorter than their predicted adult height (Boogers 2022).

• Blockers then hormones in adolescence had the desired physical effects: the trans girls look like girls and trans boys look like boys (Klaver 2018)

Also, puberty blockers have been used for decades for cis kids whose puberty starts way too early (Magiakou 2010) and for endometriosis in adolescence (Gallagher 2018).