No, I don't recommend NAD+ infusions. My friend Pooyan’s NAD+ infusion provider failed to explain how excruciating the procedure is, and how risky. Lucky he didn't kill them!

The BR-NAD+ protocol is safer, but it can still cause a crash syndrome (supps to fix this suggested at end).

Nicotinamide Riboside (NR) taken orally is really nice. I love the feeling from eating it. orthomolecular.org doctors believe niacin has the most benefits, with best safety profile and cost, but many people don't like the flush from it. Niacin is ultra relaxing and even blocks psychedelic trips and psychosis quite well at higher doses. Take niacin slowly to avoid stomach burn. Niacinamide is more helpful for ADHD/focus, but you can't mega dose it like you can niacin and NR.

There isn't any convincing evidence that injecting NAD+ is more beneficial long-term than eating NR or niacin, but NAD+ has a much stronger effect short-term. It also causes short to long-term harm to some people when they get rapid 90-min IV. Nobody wants to pay for a 4hr infusion.

Post injection crash syndrome is most likely in people with slow COMT, MTHFR, Long COVID, Chronic Fatigue Syndrome (ME/CFS), or Mold Toxicity Symptoms, this crash syndrome includes symptoms like

anxiety, brain fog, fatigue, depression, as well as painful phlebitis (venous irritation), hives, localized burning sensations, new onset food sensitivities, which can last weeks, months, or years if not addressed.

Causes: methyl group depletion, CRP elevation, increased homocysteine, glycine depletion, dehydration, liver taxation..

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Can be mostly remedied with:

3-5 days prior, but not on day of BR-NAD+: 500mg-1g TMG with breakfast and lunch, 50-100mg R5P form of riboflavin daily, 3g glycine nightly to mop up extra methyl groups.

24hrs after BR-NAD+ you should start taking these for a week:

1) 500mg of methionine with low-protein lunch to help your body improve SAMe production which NAD+ crashed

2) if you’re not slow COMT you can also supplement 400mg SAMe on an empty stomach in the morning (can double the dose if it feels weak).

3) a good active B complex containing L-5-MTHF form of folate plus methylcobalamin or adenosylcobalamin.

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There's also a risk of giving a boost to cancer development if you already have incipient cancer, since NAD+ is the fuel for it and an ultra rapid NAD infusion is highly unnatural and unstudied when it comes to this. It would be difficult to prove the correlation tho as it may take years, but reputable NAD+ providers do exclude anyone with incipient cancer detected.