I think cpalmer's figures above suggest a pretty steady impact on the unvaccinated in the UK, with the Covid vaccinated driving higher overall CFR by aging up the pool of infection-susceptible. (I've mentioned before that figures in the US are poisoned by shoddy reporting and an essentially murderous treatment protocol.) I agree there is no signal for ADE yet (except in driving more infection, but not severe outcomes).

Unless a virus phenotype includes immune evasion (sabotaging cellular immunity) / dormancy, I don't think Marek's applies. Coronavirus probably has intracellular immune evasion but this is not influenced by adaptive immunity, so vaccines can't futz with the dials. Otherwise, what exactly is the vaccine going to train the coronavirus genome to do? Make spikes faster? Again, I propose that it is already running with all relevant dials at 11.