I'm old enough to remember NSAIDS cause catastrophic stomach bleeding in everybody, cautioning news stories everywhere, and suddenly, miraculously, Big Harma had the answer: Cox-2 inhibitors! Voila!

They turned out to be dangerous, cause heart attacks, and got taken off the market in response to class action lawsuits. Huge fines for the companies ensued for HIDING NEGATIVE SAFETY DATA. Lather, rinse, repeat.