I am on Mounjaro, and have been for four months. Lost 20 pounds so far, and I'm not yet on full dosage. Occasional mild nausea but real issue for me is....tiredness. Not fatigue or exhaustion. I'm a former insomniac who can now hit the sack at 9:00 and sleep happily to 6 am, which is insanely weird.
I have been trying to lose weight for 6 years, and for most of that time been in a 20 pound range that is 100 pounds over what someone of my height should weigh. I've eaten 1500 calories a day and not lost a pound, have to drop to 1100 to lose weight verrry slowly (that's with intermittent fasting and low carbs, around 50 grams). Last year before Mounjaro I started intermittent fasting and lost 20 pounds very quickly and then stopped cold. I do not have eating issues. I don't binge. I cut out the "four white foods" six years ago because I learned that I do better on meat and cheese and vegetables than I do on pasta or bread or potatoes and vegetables. I put on weight despite walking two and in some cases four miles a day, which I can do easily.
I am ridiculously healthy and do not have an obesity diagnosis. Stone cold normal readings in A1c, glucose, cholestrol. My doctor sent me to an endocrinologist after I lost 20 pounds and then stopped cold despite the same behavior (which I still do today) because she agreed I might be insulin resistant. Endocrinologist shrugged, said it's multifactorial, but agreed that anyone with my numbers, appearance, and obvious good health was clearly doing everything right and put me on Mounjaro with no further questions. Diagnosis: insulin resistance. My insurance pays around $500 but I'm on the $25 coupon.
I didn't change a single thing about my eating habits and lost ten pounds in 2 months on the low dosage. Higher dosages have finally reduced my appetite somewhat, but my endocrinologist and I have decided to stop the increases at 12.5 (15 is the top) and then maybe even reduce, since my appetite is decreasing but the weight loss rate is constant.
Because I lost weight doing the same behavior and no drop, I'm quite convinced that something far different than appetite suppressing is also going on (fwiw, I was on phentarmine back in the day and liked it fine). Mounjaro is supposed to increase insulin production and reduce the liver's sugar production, although what that means I dunno.
I have no idea what's up with obesity but the idea that it's all about cutting intake and exercise is just stupid. I should have been losing weight for all of the past six years and haven't. Plenty of people eat healthily and are still obese. We're probably the descendants of famine survivors.
My weight is not considered a health issue. This despite the fact that my weight, for my height, is shocking. Fifty pounds below my highest weight would still leave me medically obese. 50 pounds lost moves me at most one or two clothing sizes. I can lose 30 pounds without anyone noticing.
My height and weight suggests a person needing two airplane seats, XXXXL clothing, wheezing, and inability to climb three stairs. In fact I’m in normal clothing sizes, hike and walk frequently, can run a mile if you make me, and only wheeze because of my allergies. I’m not bragging. My weight bothers me. A lot. But I’m grateful that my appearance suggests I need to lose 30-40 pounds, not 100.
My weight history was quite consistent until 2016. I have a big appetite that didn’t make me fat until I was 30. From that point on, I’d have to cut back my intake every five years or so because the same amount of calories wasn’t burning off reliably. I’d ignore my weight gain until something forced me to acknowledge it, then diet to successfully lose weight I’d keep off for five years or more. My methods are a recitation of conventional food wisdom because I always went to doctors to lose weight.
1992: start exercising, cut way back on fat. That rule, I kept as a guideline until 2016. Kept off for five years.
1997: Fenphen, just in time for the fen to be banned. But phentermine by itself kept working until 2008 or so–that is, slow weight gain but no ballooning. Then my doctor told me I couldn’t have phentermine because of my blood pressure, took me off that and put me on hydrochlorothiazide, which I’ve been on ever since (lisinopril and nifedipine added in 2016). Ending phentermine kicked off a ballooning that I ignored because I was worried that cutting calories wouldn’t work.
2010: I bit the bullet, just cut calories, and lost over 50 pounds in eight months. At that time, I vowed to monitor my weight and not ignore weight problems and over that time did pretty well. I didn’t keep all the weight off, but keeping a scale kept me from ignoring it and I’d cut back and minimize weight gains, even lose a few pounds.
In 2015, I started renting with my brother, which operated on my eating like an invasive species. His leftovers were my undoing: fettucine alfredo, fried chicken, fried fucking porkchops, fresh baguettes, and he keeps peanut butter on hand. That was when I learned that 30+ years of being solely in control of food purchases had created strictures I didn’t even know existed–like don’t buy it and you won’t eat it. It only took me a year to regroup but that year was a 30 pound weight gain and I was back to my all-time high. Wah.
2016 is when the history pattern changed. I cut calories and didn’t lose weight past a given limit. However, two things occurred that year. First, I got much better at watching my weight. I could gain ten pounds from the low limit and then lose them instead of ignoring the problem. Of equal importance, I decided to cut both calories and carbs, which focused me on carbs for the first time since the 70s and the Atkins plan.
*****
The endocrinologist is constantly asking me how my behavior changes, am I eating less, and so on, and is skeptical that I’m dropping weight with no other changes.[note--this was written six weeks ago, before recent dosage increases] My internist is much more friendly to my theory that this drug is changing my body chemistry in some way. Various reddit threads have testimonials to how the drug has stopped the taker’s binge-eating and hunger pangs. None of that applies to me. I wasn’t a binger, had no food issues, and my appetite hasn’t changed much.
My own theory is that changing my carb intake in 2016 took me off the Type 2 diabetes path, but that the insulin resistance path is unaffected by diet changes? Keep in mind I have only a vague idea what insulin does. Science is still the one subject I don’t teach. In any event, if this continues to work, my doctor agrees with me I’ll probably have to take it permanently.
**************************
I'm hoping the cost will come down, but I'm pretty sure my insurance will cover a lot of it, and I'm willing to pay quite a bit to keep weight off. It's all tax-deductible, anyway.
I am on Mounjaro, and have been for four months. Lost 20 pounds so far, and I'm not yet on full dosage. Occasional mild nausea but real issue for me is....tiredness. Not fatigue or exhaustion. I'm a former insomniac who can now hit the sack at 9:00 and sleep happily to 6 am, which is insanely weird.
I have been trying to lose weight for 6 years, and for most of that time been in a 20 pound range that is 100 pounds over what someone of my height should weigh. I've eaten 1500 calories a day and not lost a pound, have to drop to 1100 to lose weight verrry slowly (that's with intermittent fasting and low carbs, around 50 grams). Last year before Mounjaro I started intermittent fasting and lost 20 pounds very quickly and then stopped cold. I do not have eating issues. I don't binge. I cut out the "four white foods" six years ago because I learned that I do better on meat and cheese and vegetables than I do on pasta or bread or potatoes and vegetables. I put on weight despite walking two and in some cases four miles a day, which I can do easily.
I am ridiculously healthy and do not have an obesity diagnosis. Stone cold normal readings in A1c, glucose, cholestrol. My doctor sent me to an endocrinologist after I lost 20 pounds and then stopped cold despite the same behavior (which I still do today) because she agreed I might be insulin resistant. Endocrinologist shrugged, said it's multifactorial, but agreed that anyone with my numbers, appearance, and obvious good health was clearly doing everything right and put me on Mounjaro with no further questions. Diagnosis: insulin resistance. My insurance pays around $500 but I'm on the $25 coupon.
I didn't change a single thing about my eating habits and lost ten pounds in 2 months on the low dosage. Higher dosages have finally reduced my appetite somewhat, but my endocrinologist and I have decided to stop the increases at 12.5 (15 is the top) and then maybe even reduce, since my appetite is decreasing but the weight loss rate is constant.
Because I lost weight doing the same behavior and no drop, I'm quite convinced that something far different than appetite suppressing is also going on (fwiw, I was on phentarmine back in the day and liked it fine). Mounjaro is supposed to increase insulin production and reduce the liver's sugar production, although what that means I dunno.
I have no idea what's up with obesity but the idea that it's all about cutting intake and exercise is just stupid. I should have been losing weight for all of the past six years and haven't. Plenty of people eat healthily and are still obese. We're probably the descendants of famine survivors.
Anyway, I wrote about it here: https://educationrealist.wordpress.com/2022/10/09/weight-loss-and-mounjaro
Excerpts:
************
My weight is not considered a health issue. This despite the fact that my weight, for my height, is shocking. Fifty pounds below my highest weight would still leave me medically obese. 50 pounds lost moves me at most one or two clothing sizes. I can lose 30 pounds without anyone noticing.
My height and weight suggests a person needing two airplane seats, XXXXL clothing, wheezing, and inability to climb three stairs. In fact I’m in normal clothing sizes, hike and walk frequently, can run a mile if you make me, and only wheeze because of my allergies. I’m not bragging. My weight bothers me. A lot. But I’m grateful that my appearance suggests I need to lose 30-40 pounds, not 100.
My weight history was quite consistent until 2016. I have a big appetite that didn’t make me fat until I was 30. From that point on, I’d have to cut back my intake every five years or so because the same amount of calories wasn’t burning off reliably. I’d ignore my weight gain until something forced me to acknowledge it, then diet to successfully lose weight I’d keep off for five years or more. My methods are a recitation of conventional food wisdom because I always went to doctors to lose weight.
1992: start exercising, cut way back on fat. That rule, I kept as a guideline until 2016. Kept off for five years.
1997: Fenphen, just in time for the fen to be banned. But phentermine by itself kept working until 2008 or so–that is, slow weight gain but no ballooning. Then my doctor told me I couldn’t have phentermine because of my blood pressure, took me off that and put me on hydrochlorothiazide, which I’ve been on ever since (lisinopril and nifedipine added in 2016). Ending phentermine kicked off a ballooning that I ignored because I was worried that cutting calories wouldn’t work.
2010: I bit the bullet, just cut calories, and lost over 50 pounds in eight months. At that time, I vowed to monitor my weight and not ignore weight problems and over that time did pretty well. I didn’t keep all the weight off, but keeping a scale kept me from ignoring it and I’d cut back and minimize weight gains, even lose a few pounds.
In 2015, I started renting with my brother, which operated on my eating like an invasive species. His leftovers were my undoing: fettucine alfredo, fried chicken, fried fucking porkchops, fresh baguettes, and he keeps peanut butter on hand. That was when I learned that 30+ years of being solely in control of food purchases had created strictures I didn’t even know existed–like don’t buy it and you won’t eat it. It only took me a year to regroup but that year was a 30 pound weight gain and I was back to my all-time high. Wah.
2016 is when the history pattern changed. I cut calories and didn’t lose weight past a given limit. However, two things occurred that year. First, I got much better at watching my weight. I could gain ten pounds from the low limit and then lose them instead of ignoring the problem. Of equal importance, I decided to cut both calories and carbs, which focused me on carbs for the first time since the 70s and the Atkins plan.
*****
The endocrinologist is constantly asking me how my behavior changes, am I eating less, and so on, and is skeptical that I’m dropping weight with no other changes.[note--this was written six weeks ago, before recent dosage increases] My internist is much more friendly to my theory that this drug is changing my body chemistry in some way. Various reddit threads have testimonials to how the drug has stopped the taker’s binge-eating and hunger pangs. None of that applies to me. I wasn’t a binger, had no food issues, and my appetite hasn’t changed much.
My own theory is that changing my carb intake in 2016 took me off the Type 2 diabetes path, but that the insulin resistance path is unaffected by diet changes? Keep in mind I have only a vague idea what insulin does. Science is still the one subject I don’t teach. In any event, if this continues to work, my doctor agrees with me I’ll probably have to take it permanently.
**************************
I'm hoping the cost will come down, but I'm pretty sure my insurance will cover a lot of it, and I'm willing to pay quite a bit to keep weight off. It's all tax-deductible, anyway.